Strains of Escherichia coli which produce isoleucine or valine a

Details Strains of Escherichia coli which produce isoleucine or valine a Strains of Escherichia coli which produce isoleucine or valine a

1996-02-20

1997-08-19

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

435116, 4351721, 435183, 43525233, 435849, C12P 1308, C12P 1306

Patent

active

056587660

ABSTRACT:
A method for constructing microorganism strains which produce amino acids comprising: combining in one bacterial genome (a) a mutation affecting the aminoacyl-tRNA synthetase corresponding to the selected amino acid, conferring cells auxotrophy which cannot be fully suppressed by addition of usual concentration this amino acid into the culture medium and (b) a mutation which destroys the negative regulation of selected amino acid biosynthesis to yield a strain capable of increased production of the selected amino acid.
Strains producing isoleucine and valine.
Methods to produce isoleucine and valine by culturing those strains.

REFERENCES:
patent: 4391907 (1983-07-01), Matsui et al.
patent: 5175107 (1992-12-01), Debabov et al.
patent: 5534421 (1996-07-01), Livshits et al.
Derwent Abs. WPIDS 93-003491 (01) JP04330275 (Nov. 18, 1992) Ajinomoto KK.

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