Strain selection of pneumococcal surface proteins

Details Strain selection of pneumococcal surface proteins Strain selection of pneumococcal surface proteins

1996-09-20

1999-09-21

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424 9344, 4241651, 4242371, 435 734, 530350, 536 237, A61K 3909, G01N 33569, C07K 100, C07H 2104

Patent

active

059550899

ABSTRACT:
The present invention relates to vaccine composition(s) comprising at least two PspAs from strains selected from at least one family, the family being defined by PspAs from strains belonging to the family having greater than or equal to 50% homology in aligned sequences of a C-terminal region of an alpha helical region of PspA. Additionally, the families are further comprised of clades, wherein PspAs from strains which belong to a clade exhibit at least 75% sequence homology in aligned sequences of the C-terminal region of the alpha helix of PspA. Vaccine compositions of the present invention preferably comprise a minimum of 4 and a maximum of 6 strains representing a single clade each, and the at least two PspAs are optionally serologically or broadly cross-reactive.

REFERENCES:
McDaniel et al, "Localization of protection-eliciting epitopes on PspA of Streptococcus pneumoniae between amino acid residues 192 and 260", Microbial Pathogenesis, 17:323-337, Nov. 1, 1994.

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