Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Chemical stimulation of growth or activity by addition of...
Patent
1990-04-09
1992-08-18
Robinson, Douglas W.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Chemical stimulation of growth or activity by addition of...
435243, 435245, C12N 138
Patent
active
051399482
ABSTRACT:
A novel strain of Trichostrongylus colubriformis has the unique characteristics of being significantly resistant to the effect of antihelmintic drugs, in particular the antihelmintic drugs ivermectin and thiabendazole. The novel strain of T. colubriformis was prepared by the serial passage of the helminth through sheep. Twenty passages of the helminth through sheep were adequate to impart resistance to oral therapy of 20 times that normally expected with ivermectin. The highly resistant parasite is useful to screen for antihelmintic agents with different modes of action than that of ivermectin or thiabendazole which represent two of the three major classes of modern, broad spectrum anthelmintics.
REFERENCES:
Maclean et al. J. Helminthology "The pathogenesis of benzimidazole-resistant and benzimidazole-susceptible strains of Trichostrongylus colubriformis in the Mongolian gerbil (Meriones unguiculatus)" 61: 179-189 (1987).
Shoop et al. J. Parasitology "Laboratory Selection of a Benzimidazole-Resistant Isolate of Trichostrongylus colubriformis For Ivermectin Resistance" 70(2) 186-189 (1990).
Giordano et al, Veterinary Parasitology 30 139-148 (1988).
Egerton J. Parasit. 74(4) 1988 614-617.
Prichard Veterinary Parasitology 4 1978 pp. 243-255.
Egerton John R.
Shoop Wesley L.
DiPrima Joseph F.
Merck & Co. , Inc.
Robinson Douglas W.
Rose David L.
Williams Jane A.
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