Strain of streptomyces avermitilis capable of glycosylating aver

Details Strain of streptomyces avermitilis capable of glycosylating aver Strain of streptomyces avermitilis capable of glycosylating aver

1992-03-23

1994-05-17

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435243, C12N 120, C12N 100

Patent

active

053127536

ABSTRACT:
Avermectin compounds are glycosylated at the 4',13- Or 14a-positions by adding the avermectin compounds to the fermentation medium of a novel strain of Streptomyces avermitilis. The 13-hydroxy and 14a-hydroxy methyl groups of the avermectin compound are glycosylated with a glycosyl moiety, specifically an oleandrose group. The new strain offers the added advantage of not producing any C5-O-methylation products. The compounds are potent anthelmintic and antiparasite agents, and compositions for such uses are also disclosed.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4203976 (1980-05-01), Fisher et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.

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