Strain of Saccharomyces cerevisiae expressing the gene encoding

Details Strain of Saccharomyces cerevisiae expressing the gene encoding Strain of Saccharomyces cerevisiae expressing the gene encoding

1993-09-07

1997-04-15

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Rodent cell, per se

4352552, 536 235, C12N 118, C12N 119

Patent

active

056208928

ABSTRACT:
A modified Saccharomyces cerevisiae cell, wherein the cell expresses minK but does not express TRK1 and TRK2. Also disclosed is a process for detecting modulators of minK, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test compound, (b) assessing growth in the presence of a test compound and (c) determining an increase or decrease in potassium uptake into the Saccharomyces cerevisiae cells. MinK inhibitors are useful anti-arrhythmic or antifibrillatory agents; activators, anti-ischemic agents.

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