Strain of micro-organism Lactobacillus fermentum ME-3 as...

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Bacteria or actinomycetales

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S093100, C435S243000, C435S252900

Reexamination Certificate

active

10481713

ABSTRACT:
The strain of micro-organismLactobacillus fermentumME-3 is a novel anti-microbial and anti-oxidative probiotic. It has a high anti-microbial effect onEscherichia coli, Shigella sonnei, Staphylococcus aureus, Salmonella typhimurium,and moderate activity againstHelicobacter pyloristrains. The strain of micro-organism possesses Mn-superoxide dismutase and both its lysates and intact cells have high anti-oxidative activity, increasing the glutathione red-ox ratio in blood sera and able to capture toxic hydroxyl radicals. The strain of micro-organism could be used as a probiotic for the production of functional food (yoghurt, cheese) and non-comestibles (tablets, capsules) for the prophylaxis of intestinal and uroinfections, both for the prevention and treatment of chronic diseases, caused by prolonged oxidative stress.

REFERENCES:
patent: 5176911 (1993-01-01), Tosi et al.
patent: 6180100 (2001-01-01), Bruce et al.
patent: 6342366 (2002-01-01), Dondi et al.
patent: 6479051 (2002-11-01), Bruce et al.
patent: 2133272 (1999-07-01), None
“Infection” Dictionary.com, accessible at http://dictionary.reference.com/search?q=infection accessed on Dec. 14, 2005.
Mikelsaar, Marika, et al., “Antagonistic and Antioxidative Activity of Lactobacilli and Survival in Oxidative Milieu, American Journal of Clinical Nutrition”, vol. 73, No. 2S, Feb. 2001, p. 495S.
Sepp E., et al., “Intestinal Microflora of Estonian and Swedish Infants”, ACTA Paediatrica, vol. 86, No. 9, 1997, pp. 956-961.
Kullisaar, T., et al., “Two Antioxidative Lactobacilli Strains as Promising Probiotics”, International Journal of Food Microbiology, vol. 72, No. 3, 2002, pp. 215-224.
Mikelsaar, M., et al., “Intestinal Lactobacilli of Estonian and Swedish Children”, Microbial Ecology in Health and Disease, vol. 14, No. 2, Jun. 2002, pp. 75-80.
Annuk, H., et al., “Characterisation and Diferentiation of Lactobacilli by Lectin Typing”, Journal of Medical Microbiology, vol. 50, No. 12, Dec. 2001, pp. 1069-1074.
Songisepp, E. et al., “A New Probiotic Cheese With Antioxidative and Antimicrobial Activity”,Journal of Dairy Science, vol. 87, No. 7, 2004, pp. 2017-2023.
Sepp, E. et al., “Intestinal Microflora of Estonian and Swedish Infants”,Acta Paeditrica, 86, 1997, pp. 956-961.
Agostini, C. et al., “Probiotic Bacteria in Dietetic Products for Infants: A Commentary by Espghan Committee on Nutrition”,Journal of Pediatric Gastroenterology and Nutrition, vol. 38, No. 4, 2004, pp. 365-374.
Mukai, T. et al., “Inhibition of Binding ofHelicobacter pylorito the Glycolipid Receptors by ProbioticLactobacillus reuteri”, FEMS Immunology and Medical Microbiology, vol. 32, 2002, pp. 105-110.
Ringel, Y. et al., “The Brain, the Gut, the Food, and the Bacteria? Update on Treatment of Functional Gastrointestinal Disorders”,Medscape from WebMD, MedGenJournal, Dec. 23, 2004.
Fedorak, R. et al., “Probiotics and Prebiotics in Gastrointestinal Disorders”,Medscape from WebMD, Curr Opin Gastroenterol, vol. 20(2), 2004, pp. 146-155.
Reid, G. et al., “Potential Uses of Probiotics in Clinical Practice”,Clinical Microbiology Reviews, Oct. 2003, pp. 658-672.
Umezawa, K. et al., “Granulation in Livers of Mice Infected WithSalmonella typhimuriumis Caused by Superoxide Released From Host Phagocytes”,Infection and Immunity, vol. 63, No. 11, Nov. 1995, pp. 4402-4408.
Suzuki, H. et al.,Helicobacter pylori-Associated Gastric Pro- and Antioxidant Formation in Mongolian Gerbils,Free Radical Biology&Medicine, vol. 26, Nos. 5/6, 1999, pp. 679-684.
Storz, G. et al., “Oxidative Stress”,Current Opinion in Microbiology, vol. 2, 1999, pp. 188-194.
Tseng, H. et al., “Accumulation of Manganese inNeisseria gonorrheacorrelates With Resistance to Oxidative Killing by Superoxide Anion and is Independent of Superoxide Dismutase Activity”,Molecular Biology, vol. 40(5), 2001, pp. 1175-1186.
Archibald, F. et al., “Manganese and Defenses Against Oxygen Toxicity inLactobacillus plantarum”, Journal of Bacteriology, vol. 145, No. 1, Jan. 1981, pp. 442-451.
Seib, K. et al., “Defenses Against Oxidative Stress inNeisseria gonorrheaandNeisseria meningitidis: Distinctive Systems for Different Lifestyles”,The Journal of Infection Diseases, vol. 190, 2004, pp. 136-147.
Kullisaar, T. et al., “Two Antioxidative Lactobacilli Strains as Promising Probiotics”,International Journal of Food Microbiology, vol. 72, 2002, pp. 215-224.
Truusalu, K. et al., “The Influence of Antibacterial and Antioxidative Probiotic Lactobacilli on Gut Mucosa in a Mouse Model ofSalmonellaInfection”,Microbial Ecology in Health and Disease, vol. 16, 2004, pp. 180-187.
Mikelsaar, R. et al., B-1699 Probiotic Lactobacilli Enhance Eradication ofSalmonella typhimuriumin Animal Model,44thInterscience Conference on Antimicrobial Agents and Chemotherapy(Abstract), Oct. 30-Nov. 2, 2004, p. 61.
Cherbut, C. et al., “The Prebiotic Characteristics of Fructooligosaccharides are Necessary for Reduction of TNBS-Induced Colitis in Rats”,The American Society For Nutritional Sciences, J. Nutr., vol. 133, Jan. 2003, pp. 21-27.
Product Brochure, Hellus, AS Tallinna Piim (Tallinn Dairy Ltd.) date unknown.
Mikelsaar, M. et al., “Human Lactic Acid Microflora and its Role in the Welfare of the Host”,Lactic Acid Bacteria Microbiological and Functional Aspects, Third Edition, Marcel Dekker, Inc. 2004, pp. 453-505.
Annuk, H. et al., “Characterization of Intestinal Lactobacilli as Putative Probiotic Candidates”,Journal of Applied Microbiology, vol. 94, 2003, pp. 403-412.
Mikelsaar, M. et al., “Intestinal Lactobacilli of Estonian and Swedish Children”,Microbial Ecology in Health and Disease, vol. 14, 2002, pp. 75-80.
Kullisaar, T. et al., “Antioxidative Probiotic Fermented Goats' Milk Decreases Oxidative Stress-Mediated Atherogenicity in Human Subjects”,British Journal of Nutrition, vol. 90, 2003, pp. 449-456.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Strain of micro-organism Lactobacillus fermentum ME-3 as... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Strain of micro-organism Lactobacillus fermentum ME-3 as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Strain of micro-organism Lactobacillus fermentum ME-3 as... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3728548

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.