Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Intentional mixture of two or more micro-organisms – cells,...
Reexamination Certificate
2006-11-27
2009-12-08
Afremova, Vera (Department: 1657)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Intentional mixture of two or more micro-organisms, cells,...
C424S093440, C424S093450
Reexamination Certificate
active
07628981
ABSTRACT:
Describes a new strain ofStreptococcus thermophilusssp.salivarius(deposited on 4 Dec. 2001 at the DSMZ—Deutsche Sammlung von Mikroorganismen und Zeilkulturen GmbH, Braunschweig, Germany, with accession No. DSM 14667) and edible compositions, drugs and veterinary products containing it. The use of the said strain is particularly effective in the prevention/treatment of hepatic steatosis (fatty liver) and in nonalcoholic hepatic steatosis.
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patent: 7223591 (2007-05-01), De Simone
patent: 99 29330 (1999-06-01), None
patent: 99/42568 (1999-08-01), None
patent: WO 00/72855 (2000-12-01), None
Marshall V M et al: “Fermentation of Milk byStreptococcus-salivarius-SSP-salivariusandStreptococcus-salivarius-SSP-Thermophilusand Their Use to the Yogurt Manufacturer” Journal of Applied Bacteriology, vol. 59, No. 2, 1985, pp. 147-152, XP009009568 ISSN: 0021-8847 p. 147, left-hand column, paragraph 2.
Seth Sunil G et al: “Nonalcoholic steatohepatitis.” Annals of Internal Medicine, vol. 126, No. 2, 1997, pp. 137-145, XP009006803 ISSN:0003-4819 cited in the application.
O'Conner B J et al: “Nonalcoholic fatty liver (NASH syndrome).” The Gastroenterologist. United States Dec. 1997, vol. 5, No. 4, Dec. 1997, pp. 316-329, XP009009572 ISSN: 1065-2477.
Oneta Carl M et al: “Non-alcoholic fatty liver disease: Treatment options based on pathogenic considerations.” Swiss Medical Weekly, vol. 132, No. 35-36, Sep. 7, 2002, pp. 493-505, XP009009570 ISSN: 1424-7860.
Hookman Perry et al: “Current biochemical studies of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) suggest a new therapeutic approach.” The American Journal of Gastroenterolgoy. United States Feb. 2003, vol. 98, No. 2, Feb. 2003, pp. 495-499, XP009009569 ISSN: 0002-9270.
Maher J: “The CYP2E1 knockout delivers another punch: first ASH, now NASH. Alcoholic steatohepatitis. Nonalcoholic steatohepatitits.” Hepatology (Baltimore, MD) United States Jan. 2001, vol. 33, No. 1, Jan. 2001, pp. 311-312, XP009009574 ISSN: 0270-9139.
Sahai Atul et al: “Upregulation of an Inflammatory Cytokine Osteopntin Precedes Steatohepatitis in a Mouse Model of NASH.” Hepatology, vol. 36, No. 4 Part 2, Oct. 2002, p. 405A XP009009575 53rdAnnual Meeting on the Liver; Boston, MA, USA; Nov. 1-5, 2002, HTTP://HEPATOLOGY.ASSLDJOURNALS.ORG/SCRIPTS/OM.DLL/SERVE?ACTION=SEARCHDB&SEARCHDBFOR=HOME&ID=JHEP Oct. 2002 ISSN:0270-9139.
Afremova Vera
Nixon & Vanderhye P.C.
VSL Pharamaceuticals, Inc.
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