Stored blood and liquid system pH control method and apparatus

Liquid purification or separation – Processes – Liquid/liquid solvent or colloidal extraction or diffusing...

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210639, 210927, 424 19, 424157, 2103211, 210645, 435 2, B01D 3100, B01D 1300, A61M 3100

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active

043046720

ABSTRACT:
Method and apparatus for continuous pH control of aqueous liquid systems, particularly biological and biochemical systems such as stored blood, by sorption of H.sup.+ andwith a passive ion acceptor material isolated from, but in contact with liquid of said system in a selectively permeable membrane packet. Liquid systems of interest are those with an initial pH in the range of from about 4.5 to 9.0, and the pH of the system is maintained by the invention at its initial value, or brought within, and maintained in, the range of from about 6.5 to 8.0. The ion acceptor material is selected from an inorganic, relatively water insoluble metal oxide, hydroxide, phosphate or silicate matrix, which matrix is capable of maintaining a quasi-equilibrium pH state with the aqueous liquid system. The matrixing metals are preferably selected from Ti, Al and B. The matrices may be doped with oxides or hydroxides of Mg, Ca, Zn, Fe, Cu, Co, Cr and V to permit predetermined selection of a desired quasi-equilibrium pH value, and to adjust effective base capacity. Cation (e.g., Na.sup.+ and K.sup.+) doping may be used to expand the matrix lattice structure and help maintain electric (ionic) neutrality. Typical matrix acceptor compounds are selected from Al.sub.2 O.sub.3, anhydrous Al(OH).sub.3, Al(OH).sub.3 gel (preferred), MgHPO.sub.4, and Mg.sub.2 Si.sub.3 O.sub.8.

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