Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1982-10-15
1984-09-04
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424145, 424289, A61K 3171
Patent
active
044696841
ABSTRACT:
A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25.degree. C., of from about 5.5 to about 15, preferably from about 8 to about 12, such as t-butanol, to impart storage stability to the zinc erythromycin component. The composition may additionally contain particularly selected pharmaceutically-acceptable nitrogen-containing stabilizer components, such as diisopropanolamine.
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Goldberg--Antibiotics, Their Chemistry and Non--Medical Uses, p. 102, 1959.
Balsam et al.--Cosmetics, Science & Technology, 2nd ed., vol. 1, pp. 42-43, 1972.
Chemical Abstracts 55:13767.
Batt Mary L.
Huggins James E.
Kozarek William J.
Goldstein Steven J.
Schaeffer Jack D.
Schenkman Leonard
The Procter & Gamble & Company
Witte Richard C.
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