Storage of red blood cells

Details Storage of red blood cells Storage of red blood cells

1984-10-19

1986-12-02

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

435 2, 514456, A61K 3518, A01N 102

Patent

active

046264310

ABSTRACT:
Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.
In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.
Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.

REFERENCES:
patent: 3706768 (1972-12-01), Bays
patent: 3755319 (1973-08-01), Bays
Assem et al.-Brit. Med. J. 1974, 2 (5910), pp. 93-95.
Assem et al.-Chem. Abst. vol. 81 (1974), p. 33553h.
Pfister et al.-J. Med. Chem. vol. 15 No. 10 (1972), pp. 1032-1035.

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