Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Calorimeter
Patent
1998-02-19
2000-11-21
Ludlow, Jan
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Calorimeter
206217, 206222, 206569, 215227, 215228, 215250, 215307, 220202, 220212, 220800, 220801, 422 61, 422102, G01N 2175
Patent
active
061498661
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
The present invention relates to a closure device suitable for use in performing an assay, particularly a clinical test on a biological fluid such as blood. It is an object of the invention to provide a closure device which can render the reagent used in the assay into a state assuring a reliable test result and is able to maintain this state of the reagent over a long period of storage as well as under the stress of adverse environmental conditions, and furthermore to permit the addition of the reagent into the sample under assay at a desired time.
There is a need to provide a closure device permitting the assay to be carried out under maximally protected conditions thus eliminating the error factors imposed on the assay results by the environment and reducing the contamination risk imposed by the assay on the environment.
These goals and others can be attained by virtue of the closure device according to the invention, the device having its basic construction designed into a closure assembly suitable for closing the diagnostic test vessel, into which closure device the reagent after its preparation into an advantageous state for the assay is sealed in a manner permitting the release of the reagent from the closure device into the diagnostic test vessel at a desired instant of time.
Closure devices having a similar basic construction are known in the art, and their use has been contemplated in, e.g., the preparation of pharmaceuticals. In this application, the effective therapeutic drug is prepared from its basic constituents not earlier than at its required instant of use, whereby one or a number of the constituents of the pharmaceutical product are added to the other constituents stored in a medicine bottle or similar container just before the use of the drug. Prior to its addition, the first constituent(s) may have been stored in a closed space such as, e.g., the closure of the medicine bottle, wherefrom it can be taken into use by depressing or similarly actuating action on the closure, the action opening a passageway from the interior of the closure into the medicine bottle. Closure devices having this basic construction are described, i.a., in patent publications GB 1,193,989, GB 1,479,370, EP 0,093,090, EP 0,338,349, EP 0,561,322 and EP 0,344,849.
These conventional closures fail, however, to take into account the fact that a successful test in a great number of medical or similar applications requires the reagent used in the test to be in an advantageous state for the assay and that this state can be maintained up to the test instant, which instant may be essentially deferred from the ready-for-use manufacturing instant of closure device. Moreover, the circumstances prevailing during the standby period of the closure ready-for-use state may have been unfavorable to the stability of the reagent, particularly if the test kit is intended for field use.
SUMMARY OF THE INVENTION
An essential improvement capable of overcoming these problems is offered by a closure device according to the present invention having the basic construction of a sealing closure for a diagnostic test vessel or similar container. The sealing closure comprises a body part, which is tightly mountable in the mouth of the vessel and is axially made open with a cylindrical bore. The body part further includes a lid for closing the bore end facing the test vessel in an openable manner, and a plunger with a diameter compatible with the bore of the body part. The plunger is slidably mounted in the bore so as to permit its movement into a sealed position with respect to the body part thus effecting the formation of a sealed reagent storage chamber in the space remaining between the lid of the body part bore end and the plunger.
The invention also concerns a method of assaying a sample, particularly a biological fluid, by way of reacting the sample in the test vessel with the assaying reagent formed by a reagent aliquot stored in the sealed closure and released from the closure into the test vessel. Furthe
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patent: 4192429 (1980-03-01), Yerman
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patent: 5496288 (1996-03-01), Sweeney
patent: 5752940 (1998-05-01), Grimard
Backman Henry
Hellman Tapani
Kahma Kauko
Kaplas Antti
Luotola Juhani
Ludlow Jan
Orion-yhtyma Oyj
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