Stokes shift emission spectroscopy for detection of disease...

Chemistry: analytical and immunological testing – Optical result – Spectrum analysis

Reexamination Certificate

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C436S063000, C436S064000, C436S164000, C422S082050, C356S317000, C356S318000, C250S459100, C435S029000

Reexamination Certificate

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10684896

ABSTRACT:
The Stokes shift emission spectra were measured for various samples, including tissues containing photoactive bio-molecules such as tryptophan, elastin, collagen, NADH and flavin. This new approach allows for the extraction of new information not easily obtained from the excitation and or fluorescence spectra of the same samples. For example, Stokes shift spectroscopy of tissue samples can detect disease states in humans and animals.

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Alfano et al. Stokes Shift Emission Spectroscopy of Human Tissue and Key Biomolecules. IEEE Journal of Selected Topics in Quantum Electronics, vol. 9, No. 2, Mar./Apr. 2003, pp. 148-153.
Alfano et al. Stokes Shift Emission Spectroscopy of Key Biomolecules in Human Tissues. Proceedings of SPIE, vo. 5326, 2004, pp. 1-7.

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