Stimulus-inducible protein kinase complex and methods of use the

Details Stimulus-inducible protein kinase complex and methods of use the Stimulus-inducible protein kinase complex and methods of use the

1996-08-26

1999-10-26

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

530350, 530352, C12N 912

Patent

active

059726741

ABSTRACT:
Compositions and methods are provided for treating NF-.kappa.B-related conditions. In particular, the invention provides a stimulus-inducible I.kappa.B.alpha. kinase complex, and components and variants thereof. I.kappa.B.alpha. kinase complex may be used, for example, to identify antibodies and other agents that inhibit or activate signal transduction via the NF-.kappa.B cascade. I.kappa.B.alpha. kinase complex, components thereof and/or such agents may also be used for the treatment of diseases associated with NF-.kappa.B activation.

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Kuno et al., "Identification of an I.kappa.B.alpha.-associated Protein Kinase in a Human Monocytic Cell Line and Determination of Its Phosphorylation Sites on I.kappa.B.alpha.," The Journal of Biological Chemistry 270(46):27914-27919, 1995.
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