Stimulator for bone formation

Details Stimulator for bone formation Stimulator for bone formation

1993-04-21

1996-02-27

Warden, Jill

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

514 7, 514 21, A61K 4800, C07K 200, C07K 400

Patent

active

054946620

ABSTRACT:
A stimulator for bone formation containing human interleukin 4 or an analogue thereof as an active ingredient. This stimulator is useful for the prevention and treatment of, for example, osteoporosis, osteogenesis imperfecta, injured bone and abnormality of dental and the improvement of metabolic abnormality of bone.

REFERENCES:
Y. Noma et al, Nature, 319, 640 (1986).
E. Severinson et al, Eur. J. Immunol., 17, 67 (1987).
T. R. Mosmann et al, Proc. Natl. Acad. Sci. USA, 83, 5654 (1986).
T. Yokota et al, Proc. Natl. Acad. Sci. USA, 83, 5894 (1986).
P. H. Hart et al, Proc. Natl. Acad. Sci. USA, 86, 3803 (1989).
M. Hurme et al, Biochem. Biophys. Res. Commun., 157, 861 (1988).
K. Watanabe et al, Biochem. Biophys. Res. Commun., 172, 1035 (1990).
Ueno et al., Biochem. Biophys. Res. Comm., vol. 189, pp. 1521-1526, 1992.

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