Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1996-02-23
1998-10-06
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530324, 424577, 514 12, 514 2, 435372, A61K 3818
Patent
active
058177736
ABSTRACT:
Fibroblast growth factors are used in vivo, in situ and in vitro to stimulate stem cells, hemopoiesis, the immune system, transplant donor cells, culture and/or engraftment, wherein the use of fibroblast growth factors is disclosed for the stimulation of stem cells or hemopoietic cells, supporting cells and their progeny, in vitro, in situ and in vivo, as well as corresponding engrafting sites in vivo.
REFERENCES:
patent: 4296100 (1981-10-01), Franco
patent: 4378347 (1983-03-01), Franco
patent: 4642120 (1987-02-01), Nevo
patent: 4785079 (1988-11-01), Gospodarowicz
patent: 4950483 (1990-08-01), Ksander
patent: 5024841 (1991-06-01), Chu
patent: 5198356 (1993-03-01), Liberman
patent: 5399493 (1995-03-01), Emerson
patent: 5405772 (1995-04-01), Ponting
patent: 5459058 (1995-10-01), Ledev
Mansukhani, A., et al, "Characterization of the murine BEK fibroblast growth factor (FGF) receptor: Activation by three members of the FGF family and requirement for heparin", Proc. Natl. Acad. Sci. USA, vol. 89, pp. 3305-3309, Apr. 1992.
Abboud, S.L., et al, "Peptide Growth Factors Stimulate Macrophage Colony-Stimulating Factor Stromal Cells", Blood, vol. 78, No. 1, pp. 103-109, 01 Jul. 1991.
Brockbank, K.G.M., et al, "Hemopoiesis on Purified Bone-marrow-derived Reticular Fibroblasts in vitro", Exp. Hematol., vol. 14, pp. 386-394, 1986.
Gabbianelli, M., et al, "`Pure` Human Hematopoietic Progenitors: Permissive Action of Basic Fibroblast Growth Factor", Science, vol. 249, pp. 1561-1564, 28 Sep. 1990.
Gallicchio, V.S., et al, "Basic Fibroblast Growth Factor (B-FGF) Induces Early-(CFU-s) and Late-Stage Hematopoietic Progenitor Cell Colony Formation (CFU-gm, CFU-meg, and BFU-e) by Synergizing with GM-CSF, Meg-CSF, and Erythropoietin, and Is a Radioprotective Agent in Vitro", International Journal of Cell Cloning, vol. 9, pp. 220-232, 1991.
Brandt, et al., "Effect of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor on Hematopoietic Reconstitution After High-Dose Chemotherapy and Autologous Bone Marrow Transplantation", New Eng. J. Med., vol. 318, No. 14, pp. 869-876, 07 Apr. 1988.
Partanen, J., et al, "FGFR-4, A Novel Acidic Fibroblast Growth Factor Receptor with a Distinct Expression Pattern", The Embo Journal, vol. 10, No. 6, pp. 1347-1354, 1991.
Thomas, K.A., "Fibroblast Growth Factors", Faseb J., vol. 1, pp. 434-440, 1987.
Wilson, E.L., et al, "Basic Fibroblast Growth Factor Stimulates Myelopoiesis in Long-Term Human Bone Marrow Cultures", Blood, vol. 77, No. 5, pp. 954-960, 01 Mar. 1991.
Wang, Q.-R., et al, "Dissecting the Hematopoietic Microenvironment. VI. The Effects of Several Growth Factors on the in vitro Growth of Murine Bone Marrow CFU-F", Experimental Hematology, vol. 18, No. 4, pp. 341-347, May 1990.
Keegan, K., et al, "Isolation of an Additional Member of the Fiborblast Growth Factor Receptor Family, FGFR-3", Proc. Natl. Acad. Sci. USA, vol. 88, pp. 1095-1099, Feb. 1991.
Basilico, C., et al, "The FGF Family of Growth Factors and Oncogenes", Advances in Cancer Research, vol. 59, pp. 115-165, 1992.
Abraham, J.A., et al, "Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor", Science, vol. 233, pp. 545-548, 01 Aug. 1986.
Abraham, J.A., et al, "Human Basic Fibroblast Growth Factor: Nucleotide Sequence and Genomic Organization", The EMBO Journal, vol. 5, No. 10, pp. 2523-2528, 1986.
Brunner, G., et al, "Basic Fibroblast Growth Factor Expression in Human Bone Marrow and Peripheral Blood Cells", Blood, vol. 81, No. 3, pp. 631-638, 01 Feb. 1993.
Brunner, G., et al, "Phospholipase C Release of Basic Fibroblast Growth Factor from Human Bone Marrow Cultures as a Biologically Active Complex with a Phosphatidylinositol-anchored Heparan Sulfate Proteoglycan", The Journal of Cell Biology, vol. 114, No. 6, pp. 1275-1283, Sep. 1991.
Moscatelli, "Fibroblast Growth Factors", Cytokines of the Lung, Kelly, ed., Marcel Dekker, Inc., New York, pp. 41-76, 1992.
Florkiewicz, R.Z., et al, "Human Basic Fibroblast Growth Factor Gene Encodes Four Polypeptides: Three Initiate Translation From Non-AUG Codons", Proc. Natl. Acad. Sci. USA, vol. 86, pp. 3978-3981, Jun. 1989.
Huang, S., et al, "Formation of Haematopoietic Microenvironment and Haematopoietic Stem Cells From Single Human Bone Marrow Stem Cells", Nature, vol. 360, No. 24, pp. 745-749, 31 Dec. 1992.
Matsui, Y., et al, "Derivation of Pluripotential Embryonic Stem Cells from Murine Primordial Germ Cells in Culture", Cell, vol. 70, pp. 841-847, 04 Sep. 1992.
Olwin, B.B., et al, "Repression of Myogenic Differentiation by aFGF, FGF, and K-FGF is Dependent on Cellular Heparan Sulfate", The Journal of Cell Biology, vol. 118, No. 3, pp. 631-639, Aug. 1992.
Olwin, B.B., et al., "Cell Surface Fibroblast Growth Factor and Epidermal Growth Factor Receptors Are Permanently Lost during Skeletal Muscle Terminal Differentiation in Culture", The Journal of Cell Biology, vol. 107, pp. 761-769, Aug. 1988.
Prats, H., et al, "High Molecular Mass Forms of Basic Fibroblast Growth Factor are Initiated by Alternative CUG Condons", Proc. Natl. Acad. Sci. USA, vol. 86, pp. 1836-1840, Mar. 1989.
Illustrated Stedman's Medical Dictionary, 24th ed., Williams and Wilkins, Baltimore, p. 860.
Resnick, J.L., et al, "Long-Term Proliferation of Mouse Primordial Germ Cells in Culture", Nature, vol. 359, pp. 550-551, 08 Oct. 1992.
Rossant, J., "Immortal Germ Cells?", Current Biology, vol. 3, No. 1, pp. 47-50, 1993.
Stemple, D.L., et al, "Isolation of a Stem Cell for Neurons and Glia from the Mammalian Neural Crest", Cell, vol. 71, pp. 973-985, 11 Dec. 1992.
Wolswijk, G., et al, "Corporation Between PDGF and FGF Converts Slowly Dividing O-2A.sup.adult Progenitor Cells to Rapidly Dividing Cells with Characteristics of O-2A.sup.perinatal Progenitor Cells", The Journal of Cell Biology, vol. 118, No. 4, pp. 889-900, Aug. 1992.
Flaumenhaft, R., et al., "Role of Extracellular Matrix in the Action of Basic Fibroblast Growth Factors: Matrix as a Source of Growth Factor for Long-Term Stimulation of Plasminogen Activator Production and DNA Synthesis", J. Cell. Physiol., vol. 140, pp. 75-81, 1989.
Rifkin, D.B., et al, "Recent Developments in the Cell Biology of Basic Fibroblast Growth Factor", J. Cell Biology, vol. 109, pp. 1-6, Jul. 1989.
Olwin, B.B., et al., "Fibroblast Growth Factor Receptor Levels Decrease during Chick Embryogenesis", J. Cell Biology, vol. 110, pp. 503-509, Feb. 1990.
Ray, J., et al., "Proliferation, differentiation, and long-term culture of primary hippocampal neurons", Proc. Nat'l Acad. Sci. USA, vol. 90, pp. 3602-3606, Apr. 1993.
Metcalf, D., et al., "Proliferative Effects of Purfied Granulocyte Colony-Stimulating Factor (G-CSF) on Normal Mouse Hemopoietic Cells", J. Cell. Physiol., vol. 116, pp. 198-206, 1983.
Dorshkind, K., "Regulation of Hemopoiesis by Bone Marrow Stromal Cells and Their Products", Ann. Rev. Immunol., vol. 8, pp. 111-137, 1990.
Dorshkind, K., et al., "Generation of purified stromal cell cultures the support lymphoid and myeloid percursors", J. Immunol. Meth., vol. 89, pp. 37-47, 1986.
Gospodarowicz, D., et al., "Factors Involved in the Modulation of Cell Proliferation In Vivo and In Vitro: the Role of Fibroblast and Epidermal Growth Factors in the Proliferative Response of Mammalian Cells", In Vitro, vol. 14, No. 1, pp. 85-118, 1978.
Gospodarowicz, D., "Biological Activity In Vivo and In Vitro of Pituitary and Brain Fibroblast Growth Factor", Mediators in Cell Growth and Differentiation, Ford et al., eds., Raven Press, New York, pp. 109-134, 1985.
Gospodarowicz, D., et al., "Structural Characterization and Biological Functions of Fibroblast Growth Factor", Endocr. Rev., vol. 8, No. 2, pp. 95-114, 1987.
Moscatelli, D., "Metabolism of Receptor-bound and Matrix-bound Basic Fibroblast Growth Factor by Bovine Capillary Endothelial Cells", J. Cell Biol., vol. 107, pp. 753-759, Aug. 1988.
Dexter, T.M., et al., "Long-Term Marrow Culture: An Overview of Techniques and Experience", Long-Term Bone Marrow Culture, Alan R. Liss, Inc., pp. 57-96, 1984.
Fafeur, V., et al., "Basic FGF Treatment of Endothelial Cel
Gabrilove Janice
Wilson Elaine Lynette
Lukton David
New York University
Sloan-Kettering Institute for Cancer Research
Tsang Cecilia J.
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