Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1986-02-19
1989-09-19
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 14, 514912, 514915, 424427, 424429, 424450, A61K 3724
Patent
active
048681547
ABSTRACT:
A method and preparation for the stimulation of tear secretion. The method involves topically applying to the ocular surface melanocyte stimulating hormones, and their active precursors, derivatives, and fragments which activate melanotropin receptors of lacrimal gland tissue. The preparation contains a melanocyte stimulating hormone, and a vehicle for a melanocyte stimulating hormone and may also contain an ophthalmic preservative.
REFERENCES:
patent: 3991759 (1976-11-01), Urquhart
The Handbook of Non-Prescription Drugs, Fifth Ed., 1977, pp. 232, 241 and 244.
Dyster et al., "Melanocyte Stimulating Activity in Serum and the Aqueous Flair Response in Rabbits", 46(2), J. Endocrinol., pp. 285-286, (1970).
Green and Elijah, "Drug Effects on Aqueous Humor Formation and Pseudo Facility in Normal Rabbit Eyes", 33 Exp. Eye Res., pp. 239-245, (1981).
Dartt et al., Lacrimal Gland Electrolyte and Water Secretion in the Rabbit: Localization and Role of (Na.sup.+ +K.sup.+) Activated ATPase, J. Physiol., (1981), 321:559-569.
Dartt, Cellular Control of Protein Electrolyte, and Water Secretion by the Lacrimal Gland, in The Preoccular Tear Film in Health, Disease and Contact Lens Wear, (F. J. Holly, Ed.), Dry Eye Institute, Inc., Lubbock, Tex., (1986), pp. 358-370.
Friedman et al., .beta.-Adrenergic Receptor Stimulated Peroxide Secretion from Rat Lacrimal Gland, Biochem. Biophys. Acta, (1981), 675:40-45.
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"Adrenocortiocotropic Hormone and Alpha-Melanocyte-Stimulating Hormone Induce Secretion and Protein Phosphorylation in the Rat Lacrimal Gland by Activation of a cAMP-Dependent Pathway", Eur. J. Biochem, 126:623-629, (1982) John et al.
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"Vasoactive Intestinal Peptide Stimulates Outward Current in Single Lacrimal Acini Cells from Rat" Supplement to Investigative Ophthalmology & Visual Science 27(3) Mar. 1986, Lechleiter et al.
"Effect of Different Secretogogues on Lacrimal Protein Pattern", (International Tear Film Sumposium, 1984, Lubbock, Tex.), Stolze and Sommer.
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Green et al., cited in Biol. Abstracts 73(5):3566, Ref. No. 34593, 1981.
Dartt Darlene A.
Gilbard Jeffrey P.
Brown Johnnie R.
Eye Research Institute of Retina Foundation
Stone Jacqueline M.
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