Stimulation of tear secretion with cyclic nucleotides

Details Stimulation of tear secretion with cyclic nucleotides Stimulation of tear secretion with cyclic nucleotides

1988-06-27

1990-09-11

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 48, 536 27, 536 28, 536 29, A61K 3170

Patent

active

049563483

ABSTRACT:
A method and preparation for the stimulation of tear secretion. The method involves topically applying a phosphodiesterase inhibitor and/or cyclic nucleotide analogue to the ocular surface. Inhibition of phosphodiesterase and cyclic nucleotide analogues increase cyclic nucleotide levels in lacrimal gland tissue, thereby stimulating tear secretion. The preparation contains a phosphodiesterase inhibitor or a cyclic nucleotide analogue and a vehicle for the phosphodiesterase inhibitor or cyclic nucleotide analogue, and may contain an ophthalmic preservative.

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