Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1986-02-19
1988-05-17
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514912, 514915, 530308, 424110, A61K 3724, A61K 3728, G02C 704
Patent
active
047451009
ABSTRACT:
A method and preparation for the stimulation of tear secretion. The method involves topically applying to the ocular surface gastrointestinal hormones and/or biologically active peptides and their precursors, derivatives, and fragments which activate vasoactive intestinal peptide receptors of lacrimal gland tissue. The preparation contains a peptide of hormone that activates the vasoactive intestinal peptide receptor such as glucagon or vasoactive intestinal peptide, a vehicle and may also contain an ophthalmic preservative.
REFERENCES:
Gilbard and Dartt, Changes in Rabbit Lacrimal Gland Fluid Osmolarity with Flow Rate. Invest. Ophthalmoh. Vis. Sci., (1982), 23:804-806.
Mauduit et al., Protein Secretion Induced by Isoproterenol or Pentoxifylline in Lacrimal Gland: Ca.sup.2+ Effects. Am. J. Physiol., (1984), 246:C37-C44.
Stolze and Sommer, Effect of Different Scretagogues in Rabbit Lacrimal Gland Protein Secretion, in The Preoccular Tear Film in Health, Disease and Contact Lens Wear, (F. J. Holly, ed.), Dry Eye Institute, Inc., Lubbock, TX, (1986), pp. 409-416.
Dartt et al., Lacrimal Gland Electrolyte and Water Secretion in the Rabbit: Localization and Role of (Na.sup.+ +K.sup.+) Activated ATPase. J. Physiol., (1981), 321:559-569.
Dartt, Cellular Control of Protein Electrolyte, and Water Secretion by the Lacrimal Gland. In The Preoccular Tear Film in Health, Disease and Contact Lens Wear. (F. J. Holly, ed.) Dry Eye Institute, Inc., Lubbock, TX, (1986), pp. 358-370.
Friedman et al., B-Adrenergic Receptor Stimulated Peroxide Secretion from Rat Lacrimal Gland, Biochim. Biophys. Acta (1981), 675:40-45.
Dartt Darlene A.
Gilbard Jeffrey P.
Brown J. R.
Eye Research Institute of Retina Foundation
Stone Jacqueline M.
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