Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-05-26
1996-07-02
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 59, 424520, 424561, A61K 9127
Patent
active
055320015
ABSTRACT:
A method of increasing pigmentation in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of increasing pigmentation in mammalian cells, as well as a method of enhancing melanin production in mammalian melanocytes. A preparation useful in the present methods is additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, in a liposomal preparation or other appropriate vehicle. The preparation includes DNA fragments or deoxynucleotides and an appropriate delivery vehicle, such as liposomes.
REFERENCES:
patent: 3937809 (1976-02-01), Jacobi
patent: 4419343 (1983-12-01), Pauly
patent: 4866038 (1989-09-01), Hruby et al.
patent: 4956489 (1990-09-01), Auriol et al.
patent: 5352458 (1994-10-01), Yarosh
Bonte, F., et al., "Kaempferol Liposome Activity on Skin Melanogenesis", Congr. Int. Technol. Pharm. 5th(3):404-407 (1989).
Friedman, P. S., et al., "Ultraviolet radiation directly induces pigment production by cultured human melanocytes", J. Cell. Physiol. 133(1):88-94 (1987).
Niggli, H. J., et al., "Determination of Cytosine-Cytosine Photodimers in DNA of Cloudman S91 Melanoma Cells Using High Pressure Liquid Chromatography", Photochem. & Photobiol. 55(5):793-796 (1992).
Niggli, H. J., et al., "Sunlight-Induced Pyrimidine Dimers in Human Skin Fibroblasts in Comparison with Dimerization After Artificial UV-Irradiation", Photochem. & Photobiol. 48(3):353-356 (1988).
Niggli, H. J., et al., "Cyclobutane-Type Pyrimidine Photodimer Formation and Excision in Human Skin Fibroblasts After Irradiation with 313-nm Ultraviolet Light", Biochem. 22:1390-1395 (1983).
Niggli, H. J., "Comparative Studies on the Correlation Between Pyrimidine Dimer Formation and Tyrosinase Activity in Cloudman S91 Melanoma Cells After Ultraviolet-Irradiation", Photochem. & Photobiol. 52(3):519-524 (1990).
Niggli, H. J., et al., "Nucleosomal Distribution of Thymine Photodimers Following Far- and Near- Ultraviolet Irradiation", Biochem. and Biophys. Research Communications 105(3):1215-1223 (1982).
Sugitani, Yoshinori et al., "Red Shift in Photoacoustic Ultraviolet Absorption Spectra of Solid Purine Bases, Nucleosides and Nucleotides," Analytical Sciences 4:215-217 (1988).
Yaar, Mina and Gilchrest, Barbara A., "Human Melanocyte Growth and Differentiation: A Decade of New Data," Journal for Investigative Dermatology, Inc. 97(4):611-617 (1991).
Yarosh, Daniel B., et al., "Enhancement of DNA repair of UV damage in mouse and human skin by liposomes containing a DNA repair enzyme," J. Soc. Cosmet. Chem., 41:85-92-(1990).
Eller Mark
Gilchrest Barbara A.
Yaar Mina
Nutter Nathan M.
Trustees of Boston University
LandOfFree
Stimulation of tanning by DNA fragments or single-stranded DNA does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stimulation of tanning by DNA fragments or single-stranded DNA, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stimulation of tanning by DNA fragments or single-stranded DNA will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1504552