Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1995-06-06
1997-07-01
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424520, 424450, 514 44, A61K 4800, A61K 742, A61K 4730
Patent
active
056435568
ABSTRACT:
A method of stimulating pigment production in mammalian skin, as well as protecting mammalian skin against ultraviolet damage, is disclosed. Also disclosed is a method of stimulating pigment production in mammalian cells, a method of stimulating melanogenesis in mammalian melanocytes, and a culture medium for stimulating melanin production. Preparations useful in the present methods are additionally disclosed. The methods comprise administering to the epidermis or to the cells DNA fragments, either single- or double-stranded, or a mixture of both, or deoxynucleotides, dinucleotides, or dinucleotide dimers, in an appropriate vehicle, such as a liposomal preparation or propylene glycol. The preparations include DNA fragments, deoxynucleotides, dinucleotides, or dinucleotide dimers and an appropriate delivery vehicle, such as liposomes or a propylene glycol. The DNA fragments, deoxynucleotides, or dinucleotides used in the methods or in the preparations can be ultraviolet-irradiated. The preparations are sunlight-independent tanning or melanogenesis-stimulating agent.
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Eller Mark
Gilchrest Barbara A.
Yaar Mina
Chambers Jasemine C.
Hauda Karen M.
Trustees of Boston University
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