Stimulation of serotonin-1A receptors in mammals to alleviate mo

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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514657, 514872, 514922, A61K 2700, A61K 31135

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active

049434284

ABSTRACT:
A method for the alleviation of both motion sickness and chemically-induced emesis is provided which includes the administration of a nontoxic, therapeutically effective amount of a composition which stimulates serotonin-1A receptors in a mammal in need of such treatment. The preferred compounds for use are buspirone and 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT).

REFERENCES:
patent: 3930022 (1975-12-01), Hauck et al.
patent: 4076843 (1978-02-01), Hauck et al.
patent: 4087545 (1978-05-01), Archer et al.
patent: 4101677 (1978-07-01), Dunnigan et al.
patent: 4163063 (1979-07-01), Cannon et al.
patent: 4228169 (1980-10-01), Johnson et al.
patent: 4410519 (1983-10-01), Seiler et al.
patent: 4486428 (1984-12-01), Eggler et al.
patent: 4620002 (1986-10-01), Sandefur et al.
patent: 4680404 (1987-07-01), Eggler et al.
patent: 4721720 (1988-01-01), Wootton et al.
patent: 4722933 (1988-02-01), Horn
patent: 4749718 (1988-06-01), Coates et al.
patent: 4753789 (1988-06-01), Tyers et al.
Saelens, David A., Ph. D., "Antiemetic Drugs," M.U.S.C. School of Pharmacy Lecture Series, 1976, pp. 1-5.
Mansbach et al., "Discriminative Stimulus Properties of Buspirone in the Pigeon", J. Pharmacol. Exp. Ther., Feb. 1987, 240(2), pp. 364-369 (Abstract).
Goodman et al., The Pharmacological Basis of Therapeutics, 7th Ed (1985), pp. 633-634.
Colino et al., Chem. Abst. 106(1): 536m.
Marsden et al. Chem. Abst. 106(3): 12851y.
Allen et al., "Pharmacologic Effects of MJ9022-1, a Potential Tranquilizing Agent," Arzneim-Forsch, vol. 24(6), pp. 917-922 (1974).
James B. Lucot, "Blockade of 5-Hydroxytryptamine.sub.3 Receptors Prevents Cisplatin-Induced but not Motion-or Xylazine-Induced Emesis in the Cat," Pharmacology Biochemistry & Behavior, vol. 32, pp. 207-210.
Oskenberg et al., "Antagonism of 5-Hydroxytryptamine.sub.1A (5-HT.sub.1A) Receptor-Mediated Modulation of Adenylate Cyclase Activity by Pindolol and Propranolol Isomers," Biochemical Pharmacology, vol. 37, No. 18, pp. 3429-3433, 1988.
Arvidsson et al., "8-Hydroxy-2-(alkylamino)tetralins and Related Compounds as Central 5-Hydroxytryptamine Receptor Agonists", J. Med. Chem., 1984, 27, 45-51.
"Communications to the Editor", Journal of Medicinal Chemistry, 1981, 24, 921-923.
Kennett et al., "Antidepressant-Like Action of 5-HT1A Agonists and Conventional Antidepressants in an Animal Model of Depression", European Journal of Pharmacology, vol. 134, pp. 265-274 (abstract).
Tricklebank et al., "Medication of the Discriminative Stimulus Properties of 8-Hydroxy-2-(di-N-propylamino) Tetralin (8-OH-DPAT) by the Putative 5-HT1A Receptor," European Journal of Pharmacology, vol. 133, pp. 47-56 (abstract).

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