Stimulation of nerve growth and/or vitality

Details Stimulation of nerve growth and/or vitality Stimulation of nerve growth and/or vitality

1997-08-01

1999-10-19

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424 851, A61K 3818

Patent

active

059689056

ABSTRACT:
The protein, cholinergic neuronal differentiation factor (CDF), also known as leukemia inhibitory factor (LIF), is described, together with the use of the polypeptide to stimulate neuron growth and survival in animals either by direct administration or by autotransplantation of adrenal medullary cells converted to the cholinergic phenotype.

REFERENCES:
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patent: 4997929 (1991-03-01), Collins et al.
patent: 5370870 (1994-12-01), Wong et al.
Metcalf et al., "Fatal Syndrome in Mice Engrafted with Cells Producing High Levels of the Leukemia Inhibitory Factor," Proc. Natl. Acad. Sci. USA, 86(15):5948-5952 (1989).
Dunnett et al., "Acetylcholine-Rich Neuronal Grafts in the Forebrain of Rats: Effects of Environmental Enrichment, Neonatal Noradrenaline Depletion, Host Transplantation Site and Regional Source of Embryonic Donor Cells on Graft Size and Acetylcholinesterase-Positive Fibre Outgrowth," Brain Research, 378:357-373 (1986).
Norris, D.O., "Vertebrate Endocrinology" 2nd ed, Lea & Febiger:Philadelphia, pp. 238-249 (1985).
Estrov et al., "The Modulatory Hematopoietic Activities of Leukemia Inhibitory Factor," Leukemia and Lymphoma, 8:1-7 (1992).
Schehr, R.S., "Therapeutic Approaches to Alzheimer's Disease: An Informal Survey of Promising Drug Discovery Strategies," Bio/Technology, 12:140-144 (1994).
U.S. Congress, Office of Technology Assessment, "Neural Grafting: Repairing the Brain and Spinal Cord," OTA-BA-462, U.S. Government Printing Office:Washington, D.C., pp. 37-57 (1990).
Barres et al., "Multiple Extracellular Signals are Required for Long-Term Oligodendrocyte Survival," Development, 118:283-295 (1993).
Hilton et al., "Leukemia Inhibitory Factor: A Biological Perspective," Journal of Cellular Biochemistry, 46:21-26 (1991).
Yamamori et al., "The Cholinergic Neuronal Differentiation Factor from Heart Cells is Indentical to Leukemia Inhibitory Factor," Science, 246:1412-1416 (1989).
Cheema et al., "Leukemia Inhibitory Factor (LIF) Prevents the Death of Axotomized Sensory Neurons in Newborn Rat Dorsal Root Ganglion (DRG) In Vivo," So. Neurosci. Abstract, Abstract 27.2 18(1):47 (1992).
Richards et al., "Leukemia Inhibitory Factor Promotes the Neuronal Developmental of Spinal Cord Precursors From the Neural Tube," Journal of Neuroscience Research, 33:476-484 (1992).
Fukada, K., "Purification and Partial Characterization of a Cholinergic Neuronal Differentiation Factor," Proc. Natl. Acad. Sci. USA, 82:8795-8799 (1985).
Metcalf et al., Blood 76:50-56, Jul. 1990.

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