Stimulation of hair growth with minoxidil and a 5.alpha.-reducta

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514284, A61K 31505, A61K 3144

Patent

active

055785999

ABSTRACT:
An improved method and composition for promoting hair growth in mammals for treating various forms of alopecia or male pattern baldness comprising the concomitant administration of potassium channel openers, such as minoxidil, cromakalim, pinacidil, or a compound selected frown the classes of s-triazine, thiane-1-oxide, benzopyran and pyridinopyran compounds; and a 5.alpha.-reductase inhibitors, 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one. The method comprises administering an effective amount of the potassium channel opener and administering an effective amount of the 17.beta.-(N-tert-butylcarbamoyl)-4-aza-5-.alpha.-androst-1-en-3-one whereby the promotion of hair growth is increase over the sole administration of the potassium channel opener.

REFERENCES:
patent: 4139619 (1979-02-01), Chidsey, III
patent: 4596812 (1986-06-01), Chidsey, III et al.
patent: 4684635 (1987-08-01), Orentreich et al.
patent: 5026691 (1991-06-01), Kligman et al.

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