Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1995-10-06
1998-11-10
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424 701, 514880, 514881, 514258, 514260, 514554, A61K 9127, A61K 706
Patent
active
058340149
ABSTRACT:
A novel method and delivery system for therapeutic weak acid or base materials has been developed. The method and delivery system utilize a therapeutic material which is modified to make it more hydrophilic and encapsulated in a lipid vesicle, preferably a non-phospholipid lipid vesicle. The method and delivery system is particularly well suited to topical delivery of minoxidil.
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Hu, Z., et al. "Topical delivery of Ciclosporin-A From Nonionic Liposomal Systems: An in Vivo/in Vitro Correlation Study Uaing Hairless Mouse Skin," STP Pharma Sci., 4: 466-469 (1994).
Lieb, L., et al. "Follicular (Pilosebaceous Unit) Deposition and Pharmacological Behavior of Cimetidine as a Function of Formulation, " Pharm. Res., 11: 1419-1423 (1994).
Niemiec, S.M., et al. "The Effect of Dosing Volume on the Disposition of Ciclosporin-A in Hairless Mouse Skin After Topical Application of a Nonionic Liposomal Formulation: An in Vitro Diifusion Study," STP Pharma Sci., 4: 145-149 (1994).
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Chandrasekharan Ramachandran
Egbaria Kamel
Wallach Donald F.H.
Weiner Norman
Kishore Gollamudi S.
Micro-Pak, Inc.
The Regents of the University of Michigan
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