Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-12-04
2007-12-04
Allen, Marianne P. (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S014800, C424S422000, C424S486000, C424S491000, C530S326000
Reexamination Certificate
active
11038014
ABSTRACT:
Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.
REFERENCES:
patent: 4637931 (1987-01-01), Schmitz
patent: 5352664 (1994-10-01), Carney et al.
patent: 5500412 (1996-03-01), Carney et al.
patent: 5876452 (1999-03-01), Athanasiou et al.
patent: 6001352 (1999-12-01), Boyan et al.
patent: 6894027 (2005-05-01), Carney et al.
patent: 6914050 (2005-07-01), Carney et al.
patent: 04-279520 (1992-10-01), None
patent: 10-033657 (1998-02-01), None
patent: WO 95/13767 (1995-05-01), None
patent: WO 96/10426 (1996-04-01), None
patent: WO 99/08728 (1999-02-01), None
patent: WO 02/05836 (2002-01-01), None
patent: WO 02/07748 (2002-01-01), None
Alden, T.D., et al., “The Use of Bone Morphogenetic Protein Gene Therapy in Craniofacial Bone Repair,”J. of Craniofacial Surgery11(1):24-30 (2000).
Lind, M., et al., “Osteogenic Protein 1 Device Stimulates Bone Healing to Hydroxyapaptite-Coated and Titanium Implants,”J. of Arthroplasty15(3):339-346 (2000).
Lee, Y.M., et al., “The Bone Regenerative Effect of Platelet-Derived Growth Factor-BB Delivered with a Chitosan/Tricalcium Phosphate Sponge Carrier,”J. of Periodontology71(3): 418-424 (2000).
Brager, M.A., et al., “Osteogenic Growth Peptide Normally Stimulated by Blood Loss and Marrow Ablation has Local and Systemic Effects on Fracture Healing in Rats,”J. of Orthopaedic Res. 18(1):133-139 (2000).
Hong, L, et al., “Bone Regeneration at Rabbit Skull Defects Treated with Transforming Growth Factor-β1 Incorporated into Hydrogels with Different Levels of Biodegradability,”J. of Neurosurgery92(2):315-325 (2000).
Heckman, J.D., et al., “Bone Morphogenetic Protein But Not Transforming Growth Factor-β Enhances Bone Formation in Canine Diaphyseal Nonunions Implanted with a Biodegradable Composite Polymer,”J. of Bone&Joint Surgery81(12): 1717-1729 (1999).
Radomsky, M.L, et al., “Novel Formulation of Fibroblast Growth Factor-2 in a Hyaluronan Gel Accelerates Fracture Healing in Nonhuman Primates,”J. of Orthopaedic Res. 17(4):607-614 (1999).
Boyan, B.D., et al., “Potential of Porous Poly-D,L-Lactide-Co-Glycolide Particles as a Carrier for Recombinant Human Bone Morphogenetic Protein-2 During Osteoinduction In Vivo,”J. of Bio. Materials Res. 46(1):51-59 (1999).
Kato, T., et al., “Single Local Injection of Recombinant Fibroblast Growth Factor-2 Stimulates Healing of Segmental Bone Defects in Rabbits,”J. of Orthopaedic Res. 16(6):654-659 (1998).
Kirker-Head, C.A., et al., “Healing Bone Using Recombinant Human Bone Morphogenetic Protein 2 and Copolymer,”Clin. Orth.&Related Res. 349:205-217 (1998).
Kirker-Head, C.A., et al., “Long-Term Healing of Bone Using Recombinant Human Bone Morphogenetic Protein 2,”Clinical Orth. 318:222-230 (1995).
Carney, D.H., “Postclotting Cellular Effects of Thrombin Mediated by Interaction With High-Affinity Thrombin Receptors,” in Thrombin: Structure and Function, ed. Lawrence J. Berliner. Plenum Press, New York, 351-396 (1992).
Stiernberg, J., et al., “The Role of Thrombin and Thrombin Receptor Activating Peptide (TRAP-508) in Initiation of Tissue Repair,”Thrombosis&Haemostasis70(1):158-162 (1995).
Carney, D.H., et al., “Enhancement of Incisional Wound Healing and Neovascularization in Normal Rats by Thrombin and Synthetic Thrombin Receptor-Activating Peptides,”J. Clin. Invest. 89:1469-1477 (1992).
Carney, D.H., et al., “Role of High-Affinity Thrombin Receptors in Postclotting Cellular Effects of Thrombin,”Seminars in Thrombosis and Haemostasis18(1):91-102 (1992).
Stiernberg, J., et al., “Acceleration of Full-Thickness Wound Healing in Normal Rats by the Synthetic Thrombin Peptide, TP508,”Wound Repair and Regeneration8(3):204-215 (2000).
Glenn, K.C., et al., “Synthetic Peptides Bind to High-Affinity Thrombin Receptors and Modulate Thrombin Mitogenesis,”Peptide Res. 1(2):65-73 (1998).
Sower, L.E., et al., “Thrombin Peptide, TP508, Induces Differential Gene Expression in Fibroblasts Through a Nonproteolytic Activation Pathway,”Exp. Cell Res. 247:422-431 (1999).
Crowther, R.S., et al., “Thrombin Peptide TP508 Significantly Accelerates Repair of Fresh Fractures,”Distributed at Texas Mineralized Tissue Society, Austin, Texas. Aug. 1998.
Simmons, D.J., et al., “Acceleration of Rat Femoral Fracture Healing by a Synthetic Thrombin Peptide,”Calcium Metabolism: Comparative Endocrinology. Proc Satellite Meeting, San Francisco, CA. Nov. 30, 1998. (Eds. C Dacke, J Danks, G Flik and C Gay). BioScientifica Ltd. Bradley Stoke, Bristol, UK (1999).
Yang, et al., “Accelerated Repair of Segmental Defects by a Synthetic Thrombin Peptide,” Handout that was distributed at the Texas Mineralized Tissue Society Meeting (Sep. 1999).
Bi, L.X., et al., “Thrombin Peptide TP508 Regulates BMP-2 and -7 Expression by Human Osteoblasts,”Journal of Bone and Mineral Research16(1):S261 (2001).
Wang, H., et al., “Effect of TP508, a thrombin-related peptide, on Cbfal, VEGF, and collagen type II expression during femoral fracture healing,”Molecular Biology of the Cell2:243a (2000).
Wells, J.A., “Additivity of Mutational Effects in Proteins”,Biochemistry29(37):8509-8517 (1990).
Simmons, D.J., et al., “Thrombin Peptide Significantly Accelerates Repair of Fresh Fractures in Rats,”Transactions24:489 (1999).
Bi, L.X., et al., “Thrombin Peptide TP508 Regulates BMP-2 and -7 Expression By Human Osteoblasts,”J. Bone and Mineral Research16(Suppl. 1):S261 (2001).
Albrektsson, et al. (Abstract) “Osteoinduction, osteoconduction and osseointegration,”Eur. Spine J. Suppl 2:S96-101 (2001).
Carney Darrell H.
Crowther Roger S.
Redin William R.
Simmons David J.
Yang Jinping
Allen Marianne P.
DeBerry Regina M.
Hamilton Brook Smith & Reynolds P.C.
Orthologic Corp.
LandOfFree
Stimulation of bone growth with thrombin peptide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stimulation of bone growth with thrombin peptide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stimulation of bone growth with thrombin peptide derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3850403