Stimulation of angiogenesis via enhanced endothelial...

Details Stimulation of angiogenesis via enhanced endothelial... Stimulation of angiogenesis via enhanced endothelial...

2006-04-18

2006-04-18

Guzo, David (Department: 1636)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093100, C424S093600, C514S04400A, C435S320100, C435S455000

Reexamination Certificate

active

07029668

ABSTRACT:
The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region intracellularly. The tangible means include a prepared DNA sequence fragment having separate and individual DNA sequenced portions coding for an heparan sulfate binding extracellular domain, a central transmembrane domain, and a cytoplasmic domain coding for the syndecan-4 polypeptide. The prepared DNA sequence unitary fragment may be delivered to endothelial cells in-situ, both under in-vivo and/or in-vitro conditions, using suitable expression vectors including plasmids and viruses. The resulting transfected endothelial cells overexpress heparan sulfate binding, core proteins; and the resulting overexpression of these proteoglycan entities causes stimulation of angiogenesis in-situ.

REFERENCES:
patent: 5486599 (1996-01-01), Saunders et al.

Affiliated with

Also associated with

Rating

Stimulation of angiogenesis via enhanced endothelial... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stimulation of angiogenesis via enhanced endothelial..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stimulation of angiogenesis via enhanced endothelial... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3563174