Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Reexamination Certificate
2005-02-08
2005-02-08
Guzo, David (Department: 1636)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
C435S091400, C435S320100, C435S366000, C435S372000, C435S371000, C435S355000, C435S365100, C435S375000, C435S455000, C435S456000, C435S069100, C435S325000, C536S023100, C536S023500
Reexamination Certificate
active
06852515
ABSTRACT:
The present invention provides tangible means and methods for stimulation of angiogenesis via enhanced endothelial expression of core proteins having a syndecan-4 cytoplasmic region intracellularly. The tangible means include a prepared DNA sequence fragment having separate and individual DNA sequenced portions coding for an heparan sulfate binding extracellular domain, a central transmembrane domain, and a cytoplasmic domain coding for the syndecan-4 polypeptide. The prepared DNA sequence unitary fragment may be delivered to endothelial cells in-situ, both under in-vivo and/or in-vitro conditions, using suitable expression vectors including plasmids and viruses. The resulting transfected endothelial cells overexpress heparan sulfate binding, core proteins; and the resulting overexpression of these proteoglycan entities causes stimulation of angiogenesis in-situ.
REFERENCES:
patent: 5486599 (1996-01-01), Saunders et al.
Michelle J. Stanley et al, The Journal of Biological Chemistry, Herpran Sulfate-mediated Cell Aggregation, vol. 270, No. 10, Mar. 10, 1995, 5077-5083.
Horowitz Arie
Simons Michael
Volk Rudiger
Beth Israel Deaconess Medical Center
Guzo David
Prashker David
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