Stimulation of an immune response with antibodies labeled with t

Details Stimulation of an immune response with antibodies labeled with t Stimulation of an immune response with antibodies labeled with t

1998-02-06

2000-07-18

Johnson, Nancy A.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

4241331, 4241371, 4241381, 4241411, 4241421, 4241551, 4241741, A61K 39395

Patent

active

060903813

ABSTRACT:
Humoral and cellular immune responses against tumor cells and infectious agents are induced in a mammal using an antibody that binds with an epitope of an antigen that is associated with a tumor or an infectious agent, and that contains at least one .alpha.-galactosyl epitope. Such an antibody is capable of forming a complex with cells that express the target epitope and with antibodies that bind .alpha.-galactosyl epitopes. Suitable antibodies include molecules that contain at least one engineered glycosylation site in the constant region of the heavy chain.

REFERENCES:
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