Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peroxide doai
Reexamination Certificate
2001-05-30
2003-02-11
Henley, III, Raymond (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peroxide doai
Reexamination Certificate
active
06518318
ABSTRACT:
FIELD OF THE INVENTION
The invention relates to the use of pharmaceuticals and dietary supplements to stimulate the transport of glucose into animal tissue, particularly muscle tissue.
BACKGROUND
One of the factors involved in the performance of muscle tissue, especially during such physical activities as prolonged exercise routines and athletic events, is the ability of the muscle tissue to transport sufficient amounts of glucose into the tissue and convert the glucose into useable energy (i.e., ATP). While a wide variety of products and techniques have been developed in an attempt to accelerate the growth and development of muscle tissue (i.e., increasing muscle mass), little activity has focused upon improving the performance of existing muscle tissue.
SUMMARY OF THE INVENTION
I have discovered that glucose transport and glycogen loading within animal tissue can be stimulated and enhanced by administering an effective amount of a pinitol compound. Such stimulated glucose transport and enhanced glycogen loading is particularly effective for enhancing the performance of muscle tissue.
I have also discovered that pinitol alone, or in combination with a synergistic amount of insulin, is effective for controlling insulin-dependent diabetes.
In summary, I have discovered: (i) a method of enhancing performance of muscle tissue comprising administering an effective amount of a pinitol compound, preferably pinitol, to a human desiring such enhanced performance, (ii) a method of increasing glycogen loading in human tissue, including muscle tissue, comprising administering an effective amount of a pinitol compound, preferably pinitol, to a human desiring such increased glycogen loading, (iii) a method of stimulating transport of glucose into human tissue, including muscle tissue, comprising administering an effective amount of a pinitol compound, preferably pinitol, to a nondiabetic human desiring such stimulated transport of glucose, and (v) a method of controlling insulin-dependent diabetes comprising administering an effective amount of a pinitol compound, preferably pinitol, with or without the conjoint administration of an effective amount of insulin, to an insulin-dependent diabetic.
REFERENCES:
patent: 4446064 (1984-05-01), Larner et al.
patent: 4952396 (1990-08-01), Sabin et al.
patent: 5091596 (1992-02-01), Kennington et al.
patent: 5112814 (1992-05-01), Sabin
patent: 5122603 (1992-06-01), Larner et al.
patent: 5124360 (1992-06-01), Larner et al.
patent: 5183764 (1993-02-01), Kennington et al.
patent: 5283260 (1994-02-01), Miller et al.
patent: 5427956 (1995-06-01), Kennington et al.
patent: 5428066 (1995-06-01), Larner et al.
patent: 5516950 (1996-05-01), Piccariello et al.
patent: 5550166 (1996-08-01), Ostlund et al.
patent: 5652221 (1997-07-01), Larner et al.
patent: 5827896 (1998-10-01), Ostlund et al.
patent: 5834473 (1998-11-01), Virtanen et al.
patent: 5906979 (1999-05-01), Allan
patent: 6277396 (2001-08-01), Dente
patent: 2001/0039297 (2001-11-01), Allan
patent: 2001/0056072 (2001-12-01), Martin-Lomas et al.
patent: 2002/0006904 (2002-01-01), Gardiner et al.
patent: WO 90/10439 (1990-09-01), None
patent: WO 90/10711 (1990-09-01), None
patent: WO 91/12335 (1991-08-01), None
patent: WO 92/00744 (1992-01-01), None
patent: WO 92/12706 (1992-08-01), None
patent: WO 96/25381 (1996-08-01), None
patent: WO 99/37309 (1999-07-01), None
patent: WO 99/59564 (1999-11-01), None
patent: WO 99/60406 (1999-11-01), None
patent: WO 00/64454 (2000-11-01), None
patent: WO 01/82921 (2001-11-01), None
Greenhaff et al., “The Nutritional Biochemistry of Creatine,”J. Nutr. Biochem.vol. 8, No. 11, pp. 610-618, 1997, Abstract, Database CAPLUS on STN, No. 128:22136.
Handa, S.S. et al., “Hypoglycaemic plants -A review,”Fitoterapia, vol. IX, No. 3, pp. 195-224, 1989.
Kennington, A.S. et al., “Low urinary chiro-inositol excretion in non-insulin-dependent disbetes mellitus, ”N. Engl. J. Med., vol. 323, No. 6, pp. 373-378, Aug. 9, 1990 (Abstract).
Klip, Amira et al., “Induction of sugar uptake response to insulin by serum depletion in fusing L6myoblasts,”American Journal of Physiology, vol. 247, No. 3, pp. E291-E296, Sep. 1984.
Malaisse, Willy J. et al., “Determinants of the selective toxicity of alloxan to the pancreatic B cell,”Proc. Natl. Acad. Sci.USA, vol. 79, pp. 927-930, Feb. 1982.
Musclelink's AnaVol-R Product Label, 2000.
Narayanan, C.R. et al., “Pinitol --a new anti-diabetic compound from the leaves ofBougainvillea spectabilis, ”Current Science, vol. 56, No. 3, pp. 139-141, Feb. 5, 1987.
Nordin, Philip, “Preferential Leaching of Pinitol from Soybeans during Imbibition,”Plant Physiology, vol. 76, No. 2, pp. 313-315, Oct. 1984.
Ostlund, Richard E. et al., “D-chiro-Inositol metabolism in diabetes mellitus,”Proc. Natl. Acad. Sci.USA, vol. 90, pp. 1-6, 1993.
Pak, Yunbae et al., “In Vivo Conversion of [3H]Myoinositol to [3H]Chiroinositol in Rat Tissues,”The Journal of Biological Chemistry, vol. 267, No. 24, pp. 16904-16910, Aug. 25, 1992.
Phillips, Daniel V. et al., “Cyclitols in Soybean,”Journal of Agriculture and Food Chemistry, vol. 30, No. 3, pp. 456-458, Jan./Feb. 1982.
Plourde, Robert et al., “Synthesis and Characterization of an Insulin-Mimetic Disaccharide,”Journal of Organic Chemistry, vol. 57, No. 9, pp. 2606-2610, 1992.
Protein Technologies International,The Fiber of Choice...The Right Combination of Physiological and Functional Bebefits, 1989.
Reaven, Gerald M., “Role of Insulin Resistance in Human Disease,”Diabetes, vol. 37, pp. 1595-1606, Dec. 1988.
“Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus,”Diabetes Care, vol. 23, Supplement I, pp. S4-S18, Jan. 2000.
Smith, A.E. et al., “Occurrence of Pinitol in Foliage of Several Forage Legume Species, ”Crop Science, vol. 20, pp. 75-77, Jan./Feb. 1980.
Suzuki, Susumu et al., “Urinarychiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes,”Diabetes Care, vol. 17, No. 12, pp. 1465-1468, Dec. 1994.
Yasu, Takeshi, “Dissimilarity in Low Molecular Weight Carbohydrate Composition of the Seeds of Cultivated Soybean [Glycine max(L.) MERRILL subsp. max]and Wild Soybean [G. max subsp. soja (SIEB ET ZUCC.) OHASHI],”Agric. Biol. Chem., vol. 49, No. 4, pp. 933-937, 1985.
Henley III Raymond
Sherrill Michael S.
LandOfFree
Stimulating transport of glucose into animal tissue by the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stimulating transport of glucose into animal tissue by the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stimulating transport of glucose into animal tissue by the... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3161589