Stimulating the differentiation of preadipocytic cells and thera

Details Stimulating the differentiation of preadipocytic cells and thera Stimulating the differentiation of preadipocytic cells and thera

1995-08-02

1998-03-17

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514546, 514547, 514558, 514559, 514560, A61K 3107

Patent

active

057287392

ABSTRACT:
The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-.alpha. receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.

REFERENCES:
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patent: 5246723 (1993-09-01), Kameyama et al.
patent: 5278183 (1994-01-01), Silvestrini
patent: 5556844 (1996-09-01), Reichent et al.
patent: 5576349 (1996-11-01), Leaf et al.
Proceedings Eighty-Third Annual Meeting of the American Association for Cancer Research; 33:A565-6, 1992, Sporn MB et al., "Molecular and Cellular Basis for the Use of Retinoids In Chemoprevention (Meeting Abstract)".
The New England Journal of Medicine, 329(3):177-189, 1993, Warrell, R.P. Jr. et al., "Acute promyelocytic leukemia".
Safonova et al., Fatty Acids and Retinoids Act Synergistically on Adipose Cell Differentiation (See Abstract) 1994.

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