Stimulating nerve growth with immunophilins

Details Stimulating nerve growth with immunophilins Stimulating nerve growth with immunophilins

1997-09-15

2000-06-27

Caputa, Anthony C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

4241841, 4242781, 514330, A61K 31435, A61K 3144

Patent

active

060807539

ABSTRACT:
Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.

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