Stilbene derivatives and pharmaceutical compositions containing

Details Stilbene derivatives and pharmaceutical compositions containing Stilbene derivatives and pharmaceutical compositions containing

1994-09-08

1996-06-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514523, 558402, 564443, A61K 31135, C07C21784

Patent

active

055256325

ABSTRACT:
A stilbene derivative of the following general formula (I) or a pharmaceutically acceptable acid addition salt thereof have low toxicity, but are water soluble and effective as carcinostatics: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each represent an alkyl group having 1 to 3 carbon atoms; X represents a hydrogen atom or a nitrile group; Y represents an alkyloxy group having 1 to 3 carbon atoms, an alkyl group having 1 to 6 carbon atoms or a halogen atom.

REFERENCES:
patent: 5081251 (1992-01-01), Bender et al.
patent: 5430062 (1995-07-01), Cushman et al.
Cushman, M. et al., "Synthesis and Evaluation of Stilbene and Dihydrostilbene Derivatives as Potential Anticancer Agents that Inhibit Tubulin Polymerization", Journal of Medicinal Chemistry, vol. 34, No. 8, 1991 pp. 2579-2588.
Cushman, M. et al., "Synthesis and Evaluation of Analogues of (Z)-1-(4-Methoxyphenyl)-2-(3,4,5-trimethoxyphenyl) ethene as Potential cytotoxic and antimitotic Agents", Journal of Medicinal History, vol. 35, No. 12, 1992, pp. 2293-2306.
Viel, C., Abstract No. 13525, Chemical Abstracts, vol. 79, No. 3, p. 21 (1973).
Hartmann et al., "Ring-Substituted 1,2-Dialkylated 1,2-Bis(hydroxyphenyl) ethanes. 2. Synthesis and Estrogen Receptor Binding Affinity of 4-4'-5,5', and 6,6'-Disubstituted Metahexestrols", Journal of Medicinal Chemistry, vol. 27, No. 5, 1984, pp. 577-585.
Stewart, J. T., "Synthesis and Biological Evaluation of substituted .alpha.-Phenylcinnamonitriles", Journal of Pharmaceutical Sciences, vol. 60, No. 8, 1971, pp. 1244-1245.
Olszewski et al, J. Org. Chem., vol. 59 (1994), pp. 4285-4296.

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