Stilbene derivatives

Details Stilbene derivatives Stilbene derivatives

1993-08-05

1995-01-03

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544 59, A61K 3138, C07D27912

Patent

active

053787056

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are lower-alkyl; or together are alkylene with 3-5 C-atoms in a straight chain; one of the residues R.sup.3 and R.sup.4 is hydrogen and the other is hydrogen or lower-alkyl; R.sup.6 and R.sup.7 are hydrogen or lower-alkyl; R.sup.5 and R.sup.8 are hydrogen, lower-alkyl, lower-alkoxy or halogen; X signifies --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.9 ; R.sup.9 is hydrogen, lower-alkyl or acyl; Y is --S(O).sub.m R.sup.10 or --NHet and, where X is --NR.sup.9 --, --S--, --SO-- or --SO.sub.2 --, also --N(R.sup.11).sub.2 or --OR.sup.12 ; R.sup.10 is lower-alkyl; R.sup.11 and R.sup.12 are hydrogen, lower-alkyl or acyl; --NHet is a 5-8 membered, saturated or unsaturated, monocyclic heterocycle attached via a N-atom; n is 2, 3 or 4 and m is 0, 1 or 2, are described. The compounds of formula I are useful as agents for the treatment of disorders such as neoplasms, dermatoses or ageing of the skin.

REFERENCES:
patent: 3437607 (1969-04-01), Nashu et al.
patent: 3483209 (1969-12-01), Mizzoni
patent: 3630680 (1971-12-01), Rittersdorf et al.
patent: 4105681 (1978-08-01), Bollag et al.
patent: 4193931 (1980-03-01), Loeliger
patent: 4284637 (1981-08-01), Kikumoto et al.
patent: 4326055 (1982-04-01), Loeliger
patent: 4369310 (1983-01-01), Postle
patent: 4396553 (1983-08-01), Klaus et al.
patent: 4422969 (1983-12-01), Beecken
patent: 4870219 (1989-09-01), Klaus et al.
patent: 4935560 (1990-06-01), Klaus et al.
patent: 4990703 (1991-02-01), Klaus et al.
patent: 5001276 (1991-03-01), Klaus et al.
patent: 5073544 (1991-12-01), Peck et al.
Chemical Abstracts 87: 69720y (1977).
Chemical Abstracts 76: 127329p (1972).
Chemical Abstracts 107: 87107q (1987).
Naruto, et al., Synthesis and Spasmolytic Activity of 2-substituted-3-(w-dialkylaminoalkoxyphenyl)acrylonitriles and Related Compounds, Chem. Pharm. Bull. 31(6) pp. 2023-2032 (1983).
Weygand-Hilgetag, Experimental Methods in Organic Chemistry Moscow, (pp. 333, 413 and 584) (1968).
Loeliger et al. Arotinoids, A new class of highly active retinoids, Eur. J. Med. Chem-Chimica Therapeutica, Jan.-Feb., pp. 9-15 (1980).
Chemical Abstracts 102:176409d (1984).

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