Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1985-07-08
1988-02-02
Killos, Paul J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
560104, 562405, 562495, 514544, 514568, 514569, C07C 6976
Patent
active
047230282
ABSTRACT:
The application discloses certain stilbene compounds, pharmaceutical compositions thereof, method of treating thereof, method of diagnosis therewith, and method for the preparation thereof. The compounds and compositions are useful for diagnosis of leukemia types, the treatment of dermatological disorders, and as differentiation-inducing agents for neoplastic cells.
REFERENCES:
Chemica Therapeutica, Jan.-Feb., 1980-15, No. 1, pp. 9-15; "Arotinoids, A New Class of Highly Active Retinoids", by Peter Loeliger, et al.
Breitman T. R., et al., Induction of Differentiation of the Human Promyelocytic Leukemia Cell Line (HL-60) by Retinoic Acid, Proc. Natl. Acad. Sci., 77, 2936-2940, (1980).
Moon, R. C. et al., Inhibition of Carcinogenesis by Retinoids, Cancer Research Suppl., 43, 2469s-2475s, (1983).
Pawson, et al., Retinoids at the Threshold: Their Biological Significance and Therapeutic Potential, J. Med. Chem., 25, 1269, 1277, (1982).
Mayer, et al., Retinoids, a New Class of Compounds with Prophylactic and Therapeutic Activities in Oncology and Dermatology, Experientia, 34, 1105-1119, (1978).
Koeffler P., Induction of Differentiation of Human Acute Myelogenous Leukemia Cells: Therapeutic Implications, J. Am. Soc. Hematology, 62, 709-721, (1983).
Hueschen Gordon W.
Killos Paul J.
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