Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1993-05-13
1996-03-12
Fleisher, Mindy
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C07K 1447
Patent
active
054986966
ABSTRACT:
A nuclear protein which binds sterol regulatory elements (SREs), such as SRE-1 of the low density lipoprotein (LDL) receptor gene, and mediates sterol-regulated transcription of the LDL receptor gene is disclosed. Also described are screening assay and methods for the identification of agents capable of promoting LDL receptor gene transcription for use in reducing plasma cholesterol and treating the various medical problems associated therewith.
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Briggs Michael R.
Brown Michael S.
Goldstein Joseph L.
Wang Xiaodong
Board of Regents , The University of Texas System
Fleisher Mindy
McKelvey Terry A.
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