Steroids with radical-attracting aromatic substituents, process

Details Steroids with radical-attracting aromatic substituents, process Steroids with radical-attracting aromatic substituents, process

1999-02-20

1999-11-02

Dees, Jose' G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, 552500, 552610, 552612, 552615, 552625, 552626, 552638, 552639, 552641, 552648, A61K 3156, C07J 100, C07J 300, C07J 5300

Patent

active

059770961

ABSTRACT:
Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel substituted steroid compounds can be made from steroids having an estrane, androstane, pregnane or cholestane basic skeleton and have a radical-attracting aromatic substituent of the general formula --(CH.sub.2).sub.n X, or .dbd.CH--(CH.sub.2).sub.m X at the 17 or 6 position of the steroid nucleus, wherein X=Y, OY, SY, SeY or NHY; n=0 to 5; m=n-1 and Y is a phenyl group having five substituents A, B, C, D and E, wherein A to E is independently H, alkyl, Oalkyl, Oacyl, OH, or one of the substituents B, C or D is NR.sub.2 wherein R=alkyl and each of the other substituents is hydrogen. Pharmaceutical compositions containing the novel substituted steroid compounds and methods of making them are also part of the invention.

REFERENCES:
patent: 5371078 (1994-12-01), Clark et al.

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