Steroids of the 20-spiroxane series, processes for the manufactu

Details Steroids of the 20-spiroxane series, processes for the manufactu Steroids of the 20-spiroxane series, processes for the manufactu

1984-04-09

1985-11-12

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514175, 26023955R, 26023957, A61K 3158, C07J 900

Patent

active

045528713

ABSTRACT:
(5.alpha.)-20-spirox-1-en-3-ones (I) and 17-hydroxy-5.alpha.,17.alpha.-pregn-1-en-3-ones (II) of the formulae ##STR1## in which X represents O or H.sub.2, R.sub.2 represents O and R.sub.1 represents OH, OMe, OAlk, NH.sub.2, NHR.sub.3, NR.sub.3 R.sub.4, or R.sub.2 represents H.sub.2 and R.sub.1 represents OH, OAlk, OAr, OAralk or OAc,
in which R.sub.3, R.sub.4 and Alk represent lower alkyl, Me represents a metal atom or metal equivalent or the cation of an organic base, Ar represents monocyclic aryl, Aralk represents monocyclic aryl-lower alkyl, and Ac represents lower alkanoyl, monocyclic aroyl, lower alkylsulphonyl or monocyclic arylsulphonyl, it being possible for R.sub.3 together with R.sub.4 also to represent a lower alkylene group optionally interrupted by a hetero atom,
are manufactured by known analogy processes. They exhibit an aldosterone-antagonistic action and can therefore be used, for example, as potassium-conserving diuretics, optionally together with another electrolyte-non-specific diuretic or saluretic.

REFERENCES:
patent: 4079054 (1978-03-01), Green et al.
patent: 4118488 (1978-10-01), Philippson et al.

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