Steroids for the treatment of hypercholesterolemia

Details Steroids for the treatment of hypercholesterolemia Steroids for the treatment of hypercholesterolemia

1984-08-10

1987-07-14

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

2603972, A61K 3156, C07J 900

Patent

active

046802908

ABSTRACT:
Steroids of the formula ##STR1## wherein n represents the number 2, 3 or 4; R.sup.1 represents hydrogen, lower-alkyl or lower-alkylidene; R.sup.2, R.sup.3 and R.sup.4 represent hydrogen or lower-alkyl and the dotted C--C bonds in the 5(6)-, 7(8)-, 22(23)-, 24(28)- and 25(26)-position are optional, whereby the B-ring can contain only one double bond and the side-chain is either saturated or is mono-unsaturated or is di-unsaturated in the 22(23), 25(26)-position; and whereby R.sup.1 is lower-alkyl or lower-alkylidene when a 5(6)-double bond is present, n is 2 and R.sup.2, R.sup.3 and R.sup.4 are methyl,
and pharmaceutically acceptable salts of these steroids have activity inhibiting the intestinal resorption of cholesterol. They can be manufactured from steroids which are otherwise substituted in the 3.beta.-position.

REFERENCES:
patent: 3248408 (1966-04-01), Grier et al.
Chemical Abstracts (1979), vol. 91, Par. 34,466(a) relied on.
Ramirez et al., J. Org. Chem., vol. 43, No. 12 (1978), pp. 2331-2334.
Ramirez et al., Int. Journal Methods in Syn. Org. Chem., No. 10 (1977), pp. 673-675.
Chem. Abstracts 91:34466.
Chem. Abstracts 91:57297k.
Chem. Abstracts 92:53745c.
Chem. Abstracts 94:80055a.
Chem. Abstracts 89:23755.

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