Steroids derivatives as selective progesterone receptor...

Details Steroids derivatives as selective progesterone receptor... Steroids derivatives as selective progesterone receptor...

2011-07-19

2011-07-19

Badio, Barbara P (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S866000, C549S384000

Reexamination Certificate

active

07981927

ABSTRACT:
The present invention is directed to novel steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glucocorticoid receptor.

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Cook, C.E. et al.: Reversal of Activity Profile in Analogs of the Antiprogestin RU 486: Effect of a 16α-Substituent on Progestational (Agonist) Activity; Life Sciences (1993) 52(2): 155-162.
Wagner, B.L. et al.: 16α-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity; Proc. Natl. Acad. Sci. (1996) 93: 8739-8744.
PCT International Search Report for International application No. PCT/US2008/055989 dated Aug. 25, 2008.

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