Steroids

Details Steroids Steroids

1990-12-24

1992-01-14

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552530, 552531, 552632, A61K 3156

Patent

active

050811142

ABSTRACT:
A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, ##STR2## alkyl and alkoxy of 1 to 12 carbon atoms, aryl and aryloxy of 6 to 12 carbon atoms and aralkyl and aralkoxy of 7 to 12 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms or taken together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocycle optionally containing a second heteroatom of --S--, --O-- or --N--, R.sub.A is selected from the group consisting of hydrogen, halogen, --OH, alkyl, alkylthio and alkoxy of 1 to 6 carbon atoms, --NH.sub.2, mono- and dialkylamino of 1 to 6 alkyl carbon atoms, carbamoyl and alkoxy carbamoyl of up to 7 carbon atoms, X is --O-- or ##STR3## R.sub.17 is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms and the dotted lines at 1(2) and 6(7) indicates an optional double bond, with the proviso that R.sub.A is not hydrogen when R is alkoxy, aryloxy or aralkoxy having aromatic specific activity useful in treating cancers.

REFERENCES:
patent: 4054651 (1977-10-01), Bensen et al.
patent: 4150127 (1979-04-01), Anner et al.
patent: 4309423 (1982-01-01), Biollaz

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