Steroidic 5.alpha.-reductase inhibitors

Details Steroidic 5.alpha.-reductase inhibitors Steroidic 5.alpha.-reductase inhibitors

1986-02-03

1988-03-22

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514234, 514236, 514253, 514284, 2603971, 544 60, 544125, 544361, 546 77, 546 78, C07J 7300, A61K 3158

Patent

active

047328975

ABSTRACT:
The present invention relates to new 4-aza-17.beta.-substituted 5.alpha.-androstan-3-ones, to a process for their preparation, to pharmacological compostions containing them, and to the use of said compounds as inhibitors of androgen action by means of testosterone 5-reductase inhibition.

REFERENCES:
patent: 4220775 (1980-09-01), Rasmusson et al.
patent: 4377584 (1983-03-01), Rasmusson et al.
patent: 4388241 (1983-06-01), Monks
Doorenbos et al., Chemical Abstracts, vol. 63; 10017c-e (1965).
Varricchio, Chemical Abstracts, vol. 66:44027f (1967).
Shoppee et al., J. Chem. Soc. (1962), pp. 2275-2285.
Djerassi, "Steroid Reactions, an Outline for Organic Chemists", Holden-Day, Inc., San Francisco (1963), pp. 513-518.
Rasmusson G. H. et al., "Azasteroids as Inhibitors of Rat Prostatic 5-Reductase" J. Med. Chem. 1984, 27, 1690-1701.
Farmdoc Abstract 794038/44, Merck & Co., Inc. EP 4949, 1979.

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