Steroidal glycosides as antihyperlipidemic agents

Details Steroidal glycosides as antihyperlipidemic agents Steroidal glycosides as antihyperlipidemic agents

1996-07-30

1997-12-16

Owens, Amelia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 5, A61K 31705

Patent

active

056985274

ABSTRACT:
Ergostanone derivatives substituted with dissaccharides are cholesterol absorption inhibitors useful in the treatment of hypercholesterolemia and related disorders. These cholesterol absorption inhibitors may be employed alone or in combination with other cholesterol lowering agents.

REFERENCES:
patent: 4602003 (1986-07-01), Malinow
patent: 4602005 (1986-07-01), Malinow
patent: 5041541 (1991-08-01), Mazur
Harwood et al., J. of Lipid Res., vol. 32 (1993), pp. 377-395, "Pharmacologic consequences of cholesterol absorption inhibition: alteration in cholesterol metabolism and reduction...".
Melchoir et al., J. of Lipid Res., vol. 26 (1985), pp. 306-315, "Cholesterol absorption and turnover in hypercholesterolemic dogs".
Holman et al., Lab. Invet., vol. 7 (1958), pp. 42-47, "Technics for studying athersclerotic lesions".

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