Steroidal C-glycosides

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

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424 91, 514 25, 514359, 514461, 536 5, 536 6, 536 61, 536 62, 540 94, 540 95, 540 97, A61K 3170, A61K 5100, C07J 900

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active

056957386

ABSTRACT:
Compositions of sterodial glycosides are described wherein the glycoside is linked directly, or indirectly to a desired steroidal compound via a carbon, or similar stable linkage, and methods of using the compositions to treat patients by binding to and/or blocking cellular receptors for a variety of diseases including cancer, inflammation, and autoimmune diseases.

REFERENCES:
patent: 4189471 (1980-02-01), Ponpipom et al.
patent: 4229441 (1980-10-01), Bugianesi et al.
patent: 4259324 (1981-03-01), Ponpipom et al.
patent: 4562250 (1985-12-01), Staba et al.
patent: 4652637 (1987-03-01), Hagmann et al.
John C. Chabala and Tsung Y. Shen, "The Preparation of 3-Cholesteryl 6-(Glycosylthio)Hexyl Ethers and Their Incorporation into Liposomes", Carbohydrate Research, 67 (1978) 55-63.
Mitree M. Ponpipom, Robert L. Bugianesi, Tsung-Ying Shen, "Glycolipids as Potential Immunologic Adjuvants", J. Med. Chem., (1980) 23:1184-88.
M.M. Ponpipom, R.L. Bugianesi, and T.Y. Shen, "Cell Surface Carbohydrates for Targeting Studies", Can. J. Chem., (1980) 58:214.
Maarten H.D. Postema, "Recent Developments Int He Synthesis of C-Glyosides", Tetrahedron, vol. 48, No. 40, pp.8545-8599, 1992.

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