Steroidal antiestrogens and antiandrogens and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Cyclopentanohydrophenanthrene ring system containing

Reexamination Certificate

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C552S629000, C552S648000, C552S649000, C540S002000, C540S052000, C540S057000, C540S109000

Reexamination Certificate

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07041839

ABSTRACT:
The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorde. In an embodiment of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred embodiment, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.

REFERENCES:
patent: 3193564 (1965-07-01), Klimstra et al.
patent: 3401181 (1968-09-01), Klimstra
patent: 4705783 (1987-11-01), Crowe et al.
patent: 4725426 (1988-02-01), Hofmeister et al.
patent: 6677329 (2004-01-01), Loozen et al.

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