Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of H

Details Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of H Steroidal 14.alpha.-carboxy-alkyl derivatives as regulators of H

1989-08-24

1991-06-11

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552540, 552542, 552544, 552547, A61K 31575, E07J 900

Patent

active

050232509

ABSTRACT:
New 14.alpha.-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14.alpha.-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections.

REFERENCES:
patent: 4202891 (1980-05-01), Schroepfer et al.
Cooper et al., J. Chem. Soc., Chem, Commun. 898-900 (1989).
Trzaskos et al., J. Biol. Chem., 261, No. 36, 16937-42 (1986).

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