Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1987-12-17
1993-06-29
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530828, 530846, 435 691, C07K 1300
Patent
active
052236064
ABSTRACT:
A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which has been named hap, is similar to that of the DNA-binding hormone receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5 kb hap mRNA species which is undetectable in normal adult and fetal livers, but present in all non-hepatic tissues analyzed. Low stringency hybridization experiments revealed the existence of hap related genes in the human genome. The cloned DNA sequence is useful in the preparation of pure hap protein and as a probe in the detection and isolation of complementary DNA and RNA sequences.
REFERENCES:
Petkovich, M. et al. "A Human Retinoic Acid Receptor . . . " Nature, vol. 330 pp. 444-450 Dec. 3, 1987.
Evans, R. "The Steroid and Thyroid Hormone Receptor Superfamily" Science vol. 240, pp. 889-895 May 13, 1988.
de The et al. "A Novel Steroid Thyroid Hormone Receptor-Related Gene . . . " Nature, vol. 330, pp. 667-670 Dec. 17, 1987.
Benbrook et al. "A New Retinoic Acid Receptor . . . " Nature 333, pp. 669-672 Jun. 16, 1988.
Brand, N. et al. "Identification of a Second Human Retinoic Acid Receptor" Nature v. 332 pp. 853-853, Apr. 28, 1988.
Dejean, A. et al. "Hepatitis B Virus DNA Integration . . . " Nature, vol. 322, pp. 70-72, Jul. 3, 1986.
Blaudin De The Hughes
DeJean Anne
Marchio Agnes
Tiollais Pierre
Hill Jr. Robert J.
Institut Pasteur
Ossanna Nina
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