Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1988-06-20
1992-09-22
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530327, 530328, 530350, 530405, C07K 0706, C07K 0708, C07K 0710, C07K 1700, C07K 1300
Patent
active
051497816
ABSTRACT:
A previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) was used as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, which has been named hap, is similar to that of the DNA-binding hormone receptors. Six out of seven hepatoma and hepatoma-derived cell-lines express a 2.5 kb hap mRNA species which is undetectable in normal adult and fetal livers, but present in all non-hepatic tissues analyzed. Low stringency hybridization experiments revealed the existence of hap related genes in the human genome. The cloned DNA sequence is useful in the preparation of pure hap protein and as a probe in the detection and isolation of complementary DNA and RNA sequences.
REFERENCES:
Petkovich et al., "A Human Petinoic Acid Receptor which belongs to the Family of Nuclear Receptors" Nature v. 330, 444-450, Dec. 3, 1987.
Evans et al. Science 240 889-895 May 13, 1988.
de The et al. Nature 330 667-670 Dec. 17, 1987.
Benbrooh et al. Nature 333 669-672 Jun. 16, 1988.
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Dejean et al. Nature 372 70-72 Jul. 3, 1986.
Blaudin de THE Hugues
DeJean Anne
Marchio Agnes
Tiollais Pierre
Institut Pasteur
Moskowitz Margaret
Ossanna Nina
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