Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Primate cell – per se
Patent
1995-06-07
1998-08-11
Rollins, John W.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Primate cell, per se
435363, 435325, 435 701, 435 52, 435 41, C12N 500, C12P 2104, C12P 3300, C12P 100
Patent
active
057926573
ABSTRACT:
Continuous cell lines have been established from adrenocortical corcinomas. The cell lines are maintained in fully defined serum-free, steroid-free mediums. The cells of the invention, as exemplified by NCI-H295 cells, express all of the major pathways of steroid-ogenesis, including formation of corticosteroids, mineralocorticoids and androgens.
REFERENCES:
A. Leibovitz, et al.; "Brief Communication: New Human Cancer Cell Culture Lines. I. SW-13, Small-Cell Carcinoma of the Adrenal Cortex", J. Natl. Cancer Inst. 51: 691-97 (1973).
B. Fang; PNAS, USA 74: 1067 (1977).
C. Moffett, Fed. Proc. 46: 648 (1987).
D. ATCC Catalogue of Cell Lines & Hybridomas, 6th ed. pp. 63-64 (1988).
E. Staels, et al.; "Regulation of Steroidogenesis in NCI-H295 Cells: A Cellular Model of the Human Fetal Adrenal" Mol. Endo 7(3): 423-433 (1993).
F. Rainey, et al.; "Regulation of Human Adrenal Carcinoma Cell (NCI-H295) Production of C.sub.19 Steroids" J. Clin. Endo Metab 77(3): 731-737 (1993).
G. Bird, et al.; "Human NCI-H295 Adrenocortical Carcinoma Cells: A Model for Angiotensin-II Responsive Aldosterone Secretion" Endo 133(4): 1555-1561 (1993).
H. Murray, et al.; "Gap Junction Assembly and Endocytosis Correlated with Patterns of Growth in a Cultured Adrenocortical Tumor Cell (SW-13)" Cancer Res 41: 4063-4074 (Oct. 1981).
I. Alberts, et al.; Molecular Biology of the Cell pp. 335-339 (1983).
Gazdar Adi F.
La Rocca Renato V.
Myers Charles E.
Oie Herbert K.
Stein Cy A.
Rollins John W.
Rucker Susan S.
Tate Christopher R.
The United States of America as represented by the Department of
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