Steroid ointment formulation

Details Steroid ointment formulation Steroid ointment formulation

1987-11-13

1989-09-19

Sneed, H. M. S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514177, 514178, 514180, A61K 3156

Patent

active

048681687

ABSTRACT:
A steroid ointment formulation which has enhanced physical and chemical stability is formed of 11.beta.,17.alpha.)-17-(ethylthio)-9.alpha.-fluoro-11.beta.-hydroxy-17-(me thylthio)androsta-1,4-dien-3-one (tipredane), and a vehicle containing as major ingredients propylene glycol and water, cetearyl alcohol and ceteareth 20 or other dispersing agent for propylene glycol, together with a sodium or potassium citrate and magnesium hydroxide buffer to impart a neutral or slightly alkaline apparent pH (5 to 9), a non-acidic long chain fatty acid wax to impart proper consistency to the ointment and sodium metabisulfite and butylated hydroxy toluene as antioxidants, together with thickeners, emollients, lubricants and other conventional ointment formulation ingredients.

REFERENCES:
patent: 2801202 (1957-07-01), Poetsch
patent: 3856954 (1974-12-01), Jackson
patent: 4048310 (1977-09-01), Chen et al.
patent: 4233295 (1980-11-01), Hill et al.
patent: 4361559 (1982-11-01), Varma

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