Steroid monohydrates, formulations containing same and method

Details Steroid monohydrates, formulations containing same and method Steroid monohydrates, formulations containing same and method

1982-01-18

1983-07-05

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424243, C07J 500, A61K 3156

Patent

active

043917550

ABSTRACT:
A monohydrate of a steroid having the structure ##STR1## and the 1,2-dehydro derivatives thereof, is provided which monohydrate is in the form of a particulate material having a stable average particle size of less than about 20 microns. Cream and lotion formulations containing the steroid monohydrate and a method for forming the monohydrate are also provided.

REFERENCES:
patent: 3937720 (1976-02-01), Varmi et al.
Collard, R. E., "Formulation and Manufacture of Corticosteroid Preparations" (1961), Pharm. J., 186, 113-117.
Carless, et al. "Dissolution and Crystal Growth in Aqueous Suspensions of Cortisone Acetate", J. Pharm. Pharmac, 1968 20, 630-638.
Carless, et al., "Effect of Crystal Form, Cortisone Alcohol and Agitation on Crystal Growth of Cortisone Acetate in Aqueous Suspensions", J. Pharm. Pharmac. 1968, 20, 639-645.

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